PFE Historical PE Ratio Notes

— Pfizer — ticker symbol PFE — is a global pharmaceutical giant founded in 1849, known for developing and manufacturing a broad range of innovative medicines & vaccines. The company’s products cover diverse therapeutic areas, including oncology, immunology, cardiology, and infectious diseases. Revenues and earnings for Pfizer have historically been influenced by patent cycles, regulatory approvals, competitive pressures, and landmark products such as the blockbuster COVID-19 vaccine. These fundamental factors play a major role in how investors value Pfizer through the price/earnings (PE) ratio over time. When PFE launches novel treatments or benefits from surges in demand, as with the COVID-19 vaccine, earnings may spike, sometimes temporarily lowering its PE ratio if share price lags behind rapid profit growth. Conversely, loss of exclusivity on key drugs or industry-wide headwinds can compress earnings, causing the historical PE ratio to rise if prices remain steady. As you examine historical PE trends, pay close attention to major product launches, patent expirations, and one-time events in Pfizer’s timeline, as these often explain fluctuations in both earnings and the valuation multiples the market is willing to award.

On this page we presented the Pfizer Historical PE Ratio information for Pfizer' stock. The average PFE historical PE based on using the annualized quarterly earnings result at each measurement period (for the "E" in the PE calculation; and the closing price on earnings date as the "P") is 12.8. Meanwhile, using the trailing twelve month (TTM) quarterly earnings result as our method of calculation the "E" value at each measurement period, the average PFE historical PE based on this TTM earnings result method is 12.1. Note: any PE calculations involving negative earnings were discarded as not meaningful.

Let's now compare this PFE historical PE result, against the recent PE: when this page was posted on 8/14/2026, the most recent closing price for PFE had been 26.79, and the most recent quarterly earnings result, annualized, was 3.08. Meanwhile, the most recent TTM earnings summed to 3.05. From these numbers, we calculate the recent PFE PE on 8/14/2026 based on annualized quarterly EPS was 8.7. Based on PFE's history, that recent PE is low relative to the historical average, with the recent PE 32.0% lower than the historical average PE across our data set for Pfizer. Looking at the recent PFE PE on 8/14/2026 based on TTM EPS, we calculate the ratio at 8.8. Based on PFE's history, that recent PE is low relative to the historical average, with the recent PE 27.3% lower than the average PE across our Pfizer data set with TTM EPS used in the calculation at each period.

Another interesting PFE historical PE Ratio calculation we look at is to take the median earnings per share of the last four quarters for PFE, and then annualize the resulting value... with that annualized number then being used in the PE calculation. To walk through this math for PFE, we start with the past four EPS numbers and we first sort them from lowest to highest: 0.66, 0.75, 0.77, and 0.87. We then toss out the highest and lowest result, and then take the average of those two middle numbers — 0.75 and 0.77 — which gives us the median of 0.76. Basically the way to think about this 0.76 number is this: for the trailing four earnings reports, 0.76 marks the "middle ground" number where PFE has reported a value higher than 0.76 half the time, and has reported a value lower than 0.76 half the time. Annualizing that median value then gets us to 3.04/share, which we use as the denominator in our next PE calculation. With 26.79 as the numerator (as of 8/14/2026), the calculation is then 26.79 / 3.04 = 8.8 as the PFE PE ratio as of 8/14/2026, based on that annualized median value we calculated.

For self directed investors doing their due diligence on PFE or any other given stock, valuation analysis for PFE can greatly benefit from studying the past earnings and resulting PE calculations. This exercise can help inform an analysis as to whether the past earnings trajectory and current versus historical PE ratios justify the current stock value.

That's why we bring you HistoricalPERatio.com to make it easy for investors to investigate Pfizer PE history or the past PE information for any stock in our coverage universe. And in your continued research we hope you will be sure to check out the further links included for earnings surprises history (beat/miss data) as well as next earnings dates for PFE. Thanks for visiting, and the next time you need to research PFE Historical PE Ratio or the ratio for another stock, we hope you'll think of our site, as your go-to historical PE ratio research resource of choice.